During orthodontic tooth movement, bone remodeling is induced by mechanical stimulation. The mechanical regulation to stimulate the activities of osteoblasts and osteoclasts is a focus of bone studies, which also got more attention in orthodontics recently. Members of matrix metalloproteinase family (MMP) were found to be closely related to the bone remodeling during orthodontic treatment. Some studies proposed that the matrix metalloproteinase-3 (MMP-3) is related to bone resorption because the gene expression of MMP-3 was increased by orthodontic force at the compression site. Therefore, MMP-3 likely participated in bone resorption. We reviewed the studies related to the regulation of MMP-3 by mechanical stimulation in bone cells, and also investigated the relationships between bone remodeling and mechanical stimulation, and the possible mechanism of MMP-3 regulated by mechanical force.
Tsai, Shu-Chun; Tsai, Hui-Jen; Weng, Chu-Yin; Wong, Wen-Pei; Hung, Pei-Chuan; Liao, Chih-Ching; Chen, Yi-Jane; and Yao, Chung-Chen Jane
"The Regulation of MMP-3 upon Mechanical Stimulation in Bone Cells,"
Taiwanese Journal of Orthodontics: Vol. 22:
3, Article 2.
Available at: https://www.tjo.org.tw/tjo/vol22/iss3/2