The Regulation of MMP-3 upon Mechanical Stimulation in Bone Cells

Authors

Shu-Chun Tsai, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan University
Hui-Jen Tsai, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan UniversityFollow
Chu-Yin Weng, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan University
Wen-Pei Wong, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan University
Pei-Chuan Hung, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan University
Chih-Ching Liao, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan University
Yi-Jane Chen, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan University
Chung-Chen Jane Yao, Department of Orthodontics, National Taiwan University Hospital; School of Dentistry, National Taiwan University

Abstract

During orthodontic tooth movement, bone remodeling is induced by mechanical stimulation. The mechanical regulation to stimulate the activities of osteoblasts and osteoclasts is a focus of bone studies, which also got more attention in orthodontics recently. Members of matrix metalloproteinase family (MMP) were found to be closely related to the bone remodeling during orthodontic treatment. Some studies proposed that the matrix metalloproteinase-3 (MMP-3) is related to bone resorption because the gene expression of MMP-3 was increased by orthodontic force at the compression site. Therefore, MMP-3 likely participated in bone resorption. We reviewed the studies related to the regulation of MMP-3 by mechanical stimulation in bone cells, and also investigated the relationships between bone remodeling and mechanical stimulation, and the possible mechanism of MMP-3 regulated by mechanical force.

Recommended Citation

Tsai, Shu-Chun; Tsai, Hui-Jen; Weng, Chu-Yin; Wong, Wen-Pei; Hung, Pei-Chuan; Liao, Chih-Ching; Chen, Yi-Jane; and Yao, Chung-Chen Jane (2010) "The Regulation of MMP-3 upon Mechanical Stimulation in Bone Cells," Taiwanese Journal of Orthodontics: Vol. 22: Iss. 3, Article 2.
https://doi.org/10.30036/TJO.201009.0002
Available at: https://www.tjo.org.tw/tjo/vol22/iss3/2

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