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Abstract

Cleidocranio-dysplasia is an autosomal dominant disease. RUNX2(CBFA1) is the only gene known to be associated with CCD. The clinical characteristic of skeletal dysplasia including delayed or ectopic eruption of permanent teeth, multiple supernumanary teeth, delayed resorption of primary root, dilacerations of permanent and supernumanary teeth, malocclusion with skeletal discrepancy. Diagnosis of CCD in dental clinic due to oral phenomenens happened usually. This paper would systemically reviewed the genetic and pathological mechanism of CCD.

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